effect of aerobic moderate exercise intensity on plasma and aorta homocysteine and 15-f21-isoprostane concentrations in high cholesterol diet-induced atherosclerosis.
نویسندگان
چکیده
few studies have investigated the effect of exercise on homocysteine and 15-f21-isoprostane in animal models. the present study was designed to examine the effect of long-term exercise and/ or high cholesterol diet on mda, 15-f21-isoprostane and total homocysteine in the aorta and plasma of rabbits. methods: 56 male rabbits were divided into four groups: normal diet (control), normal diet with exercise, high-cholesterol diet without exercise and high cholesterol diet with exercise. animals of exercise groups ran on a treadmill at 0.88 km/h for 7.5 –90 min/day (5 days/week) for 12 weeks. at the end of exercise protocol, blood samples were collected and thcy, 15-f21-isoprostane were measured using enzyme immunoassay (eia) kits. mda levels were determined by the thiobarbituric acid assay. thoracic aorta was isolated to evaluate atherosclerosis as well as thcy, 15-f21-isoprostane and mda levels. results: exercise reduced atherogenic diet-induced atherosclerotic lesions in aorta along with positive changes in plasma cholesterol profile. atherogenic diet significantly increased plasma and aorta concentrations of mda and thcy. exercise significantly reduced diet-increased plasma and aorta concentrations of 15-f21-isoprostane and thcy in normal animals. mda levels did not show significant change due to exercise and/or high cholesterol diet feeding. there was a positive correlation among plasma cholesterol, homocysteine and 15-f21-isoprostane in exercised groups compared with control. conclusion: our results suggest that elevated homocysteine level can be considered as one of the multiple risk factors in the development of atherosclerosis. in addition, exercise may effectively reduce plasma and aorta homocysteine and 15-f21-isoprostane and may be effective in prevention and attenuation of atherosclerosis.
منابع مشابه
Effect of aerobic moderate exercise intensity on plasma and aorta homocysteine and 15-F21-isoprostane concentrations in high cholesterol diet-induced atherosclerosis.
Few studies have investigated the effect of exercise on homocysteine and 15-F21-isoprostane in animal models. The present study was designed to examine the effect of long-term exercise and/ or high cholesterol diet on MDA, 15-F21-isoprostane and total homocysteine in the aorta and plasma of rabbits. Methods: 56 male rabbits were divided into four groups: normal diet (control), normal diet wi...
متن کاملeffect of bataine and sulphate supplement on wool and milk characteristics and lambs performance in naine ewes
تعداد 20 رأس میش نژاد نائینی 6+-24 ماهه، با میانگین وزن 2/3-+40 کیلوگرم، همراه با 20 رأس بره های آنها در قالب طرح کاملا تصادفی اثر بتائین و مکمل سولفات بر خصوصیات شیر و پشم و عملکرد بره ها بررسی شد. میش ها بطور تصادفی در چهار تیمار قرار گرفتند. تیمارها عبارت بودند از: 1-گروه شاهد 2-بتائین (05/0 درصد ماده خشک) 3-سولفات (24/0 سولفور درصد ماده خشک 4-بتائین هرماه با سولفات. جیره غذائی طبق nrc با مح...
15 صفحه اولEffect of Moderate Swimming Exercise on Weight Gain in High Fat Diet Rats
Purpose: Obesity is one of the most common problems in the world. Imbalance between energy consumption and expenditure is a main factor in weight disorder. Exercise helps losing weight by increasing energy expenditure and modulation of the energy intake. The present study examined protective effects of daily moderate aerobic exercise on preventing weight gain in high fat diet rats. Materia...
متن کاملeffect of seed priming and irrigation regimes on yield,yield components and quality of safflowers cultivars
این مطالعه در سال 1386-87 در آزمایشگاه و مزرعه پژوهشی دانشگاه صنعتی اصفهان به منظور تعیین مناسب ترین تیمار بذری و ارزیابی اثر پرایمینگ بر روی سه رقم گلرنگ تحت سه رژیم آبیاری انجام گرفت. برخی از مطالعات اثرات سودمند پرایمینگ بذر را بر روی گیاهان مختلف بررسی کرده اند اما در حال حاضر اطلاعات کمی در مورد خصوصیات مربوط به جوانه زنی، مراحل نموی، عملکرد و خصوصیات کمی و کیفی بذور تیمار شده ژنوتیپ های م...
Impact of moderate-intensity aerobic exercise training on sleep quality and cardiac structure and function in inactive obese girls
Background and Aim: Aerobic exercise plays an important role in prevention of obesity, improvement of sleep quality and cardiovascular function. The purpose of this study was to investigate the effects of 8 weeks of moderate-intensity aerobic exercise training on sleep quality, and also cardiac structure and function in inactive obese girls. Materials and Methods: In this study, 20 inactive obe...
متن کاملEffect of Aerobic Exercise Training on Left Ventricular Apoptotic and Antioxidant Indices in High Fat Diet and Streptozotocin-induced Type 2 Diabetic Rat Model
Introduction: Exercise training has been suggested as a potential non-pharmacological strategy to prevent cardiovascular injuries. However, the role of exercise is controversial in preventing the progression of injuries caused by diabetic cardiomyopathy or their repairing. Therefore, this study aimed to evaluate the effect of aerobic exercise training on left ventricular apoptotic and antioxida...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
physiology and pharmacologyجلد ۱۱، شماره ۳، صفحات ۱۹۹-۲۰۷
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023